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[DOI] [PMC free article] [PubMed] [Google Scholar] 32.Yamagishi S.I., Edelstein D., Du X.L., Kaneda Y., Guzmn M., Brownlee M

Associations between abnormalities in the serotonin, noradrenaline, and dopamine pathways and the onset of fibromyalgia have been revealed in several genetic studies [17,19]

GSH depletion selectively oxidizes and destabilizes FASN

Additionally, research has shown that selenium content in the diet is negatively correlated with hypertension [19]

Since disulfiram and cocaine both affect levels of global methylation we hypothesized the MTHFR gene, whose product is involved in supplying methyl groups for DNA and protein methylation, may be associated with responsiveness to disulfiram in cocaine-dependent individuals
