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Until very recently it was difficult to measure CB1 internalization in presynaptic terminals, but a recent study using super resolution microscopy in hippocampal GABAergic terminals indicated that chronic 9 -THC treatment does indeed produce internalization of CB1 (Dudok et al., 2015)

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It shows up as a slowing of recall, difficulty sustaining concentration, and a general sense that the brain is not as sharp as it once was