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Description
Activation of the PI3K and MAPK signaling pathways downstream of the IGF-1R is thought to regulate both ZEB1/2 and Snail1/2 to promote EMT [104], although activity of other kinases downstream of the IGF-1R, such as focal adhesion kinase (FAK) and Src, have also been implicated in this process [108,109]
NP, based on systems biology, studies drug-target-disease networks, revealing the potential for multitargeted therapies
2024;11:e2400712
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