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The Trx system plays a key role in DNA synthesis, anti-apoptotic signaling, and regulation of redox-sensitive transcription factors
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During ferroptosis, NADPH is a key regulator that acts as a cofactor and functions along with GRX to reverse the conversion of GSSG to GSH, sustain the balance between GSH and GSSG, and inhibit lipid peroxidation damage (Seibt et al., 2019
H 2 , molecular hydrogen
