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Certain individuals should proceed with caution or avoid it altogether: 1

Its levels also typically decline with age

Wilkinson HA, Dahllund J, Liu H, et al

In vivo studies indicate that Pink1 is essential for maintaining normal glutamatergic signaling within striatal circuits, implicating it in the mechanisms underlying striatal dysfunction in PD

Yes, many people find that taking glutathione before bedtime is a convenient way to avoid the coffee interaction entirely
