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Stacking two appetite-active compounds can amplify them, which is the single biggest tolerability concern with any cagrilintide-plus-tirzepatide concept
The clinical trial protocol starts at 0.25 mg to 0.3 mg weekly and increases every 4 weeks through escalation steps of 0.6 mg, 1.2 mg, 1.8 mg, and finally 2.4 mg
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Pigment Cell Melanoma Res 23, 190 (2010)
J Transl Med 13:138 Burg MB, Kwon ED, Kultz D (1997) Regulation of gene expression by hypertonicity
