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However, there are still a number of non-responsive patients under IVIG treatment

doi: 10.1038/s41392-022-01190-w [DOI] [PMC free article] [PubMed] [Google Scholar] 122

Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a dual role in myddosome formation and toll-like receptor signaling

Ceruloplasmin, an abundant acute phase protein in plasma, acts as an important antioxidant, which has been shown to directly bind and inhibit MPO [322], interfere with HOCl production [323] and thus, for instance, prevent HOCl-mediated degradation of the 1 -antiproteinase and other proteins [30]

D., Carneiro, D