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Clostridial toxins A (TcdA) and B (TcdB) utilise TJ components as receptors, specifically the nectin-3 component of adhesion junctions, which leads to downstream cytoskeletal disruptions and cell death (Roxas and Viswanathan 2018)

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The correlation between red acridine orange fluorescence and LC3-II occurrence has been previously described 44 and suggests that at certain curcumin concentrations the primary events are linked to autophagic induction

The synergistic effects of these agents on monoaminergic modulation, neurotrophic signaling, inflammatory responses, oxidative stress management, and stress-response mechanisms provide a compelling mechanistic foundation for their therapeutic significance in the treatment of depressive disorders

Mercury is one of the toxic chemicals often used in skin-lightening products