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Given that there is no placebo-controlled human data, no established dose, and a mechanism whose foundational papers were retracted, an absence of noticeable effect is fully consistent with the current evidence it does not necessarily indicate a defective product, the wrong route, or an insufficient duration

The injections are typically administered intramuscularly and are known to provide quicker relief from symptoms of B12 deficiency compared to oral supplements

Unfortunately, the pharmacokinetics of the hemin in that trial were insufficient to conclusively test whether countering oxidative stress can restore normal ENS function and gastric emptying ( Potential Pharmacological Promotion of Neuronal Cell Differentiation As in other tissues, there is a dynamic balance in the enteric nervous system between cell loss by apoptosis, phagocytosis of dead cells by resident macrophages, and restoration of new cells from stem cells