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HEPATOCYTE CELL DEATH MECHANISMS AFTER APAP TOXICITY The mode of cell death after APAP-induced liver injury was controversial initially, since a number of mechanistic steps in the process, such as mitochondrial Bax translocation, release of cytochrome c64,79,88, and nuclear DNA fragmentation32, were similar to that seen during apoptosis (Fig

demonstrated that PS-NPs exposure significantly decreases EAAT2 levels in astrocytes of the medial prefrontal cortex (mPFC) in mice, diminishing glutamate uptake capacity

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levels below 200 pg/mL are generally considered deficient [*]
