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Over time, shortened telomeres are associated with: Cellular aging Reduced tissue repair Increased inflammation Declining immune function Age-related disease risk Many scientists consider telomere length to be one marker of biological agethe age of your cells and tissues, which may differ significantly from your chronological age

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Titration governs tolerability fast 2-week ramp to 15 mg gave 24.5% AE-discontinuation (Frias 2018)
