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The trials of this meta-analysis employed different dosages of B vitamins, with vitamin B 12 included in four of five trials

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Model-dependent changes in markers of cellular energy status and oxidative-stress responses

Similarly, the quinolinium containing parent analogue 1-MQ also lacked passive diffusion properties (Table 1), suggesting that the lipophilicity and drug-like permeability properties of analogues within the methylquinolinium series had to be improved via chemical modification