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However, oxygenation of the C4 position by itself appears to be challenging, and simultaneous expression of 3-hydroxybutyrate dehydrogenase 1-like (BDH1L) is required
Neuron 94 , 1936 (2017)

doi: 10.1080/01616412.2018.1462879 67 MiekusK.MadejaZ
At about 40 years of age, practically all patients with Down syndrome exhibit neuropathological changes typical for Alzheimers disease including -amyloid plaques and neurofibrillary tangles (Mann and Esiri 1989)

10.1016/j.redox.2017.07.008 [DOI] [PMC free article] [PubMed] [Google Scholar] Koskenkorva-Frank TS, Weiss G, Koppenol WH, Burckhardt S (2013) The complex interplay of iron metabolism, reactive oxygen species, and reactive nitrogen species: insights into the potential of various iron therapies to induce oxidative and nitrosative stress