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Pyruvate + CoA + NAD + Acetyl-CoA + NADH + H + + CO 2 The acetyl group can enter the citric acid cycle to be completely oxidized to carbon dioxide, with the production of a molecule of GTP, 3 molecules of NADH, one of FADH 2

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Indeed, iron-depletion rapidly results in cellular death

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Figure 1 Conflict of interest statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest