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To date, phase III clinical trials have failed to demonstrate anti-cancer efficacy of vitamin C with the exception of patients with KRAS mutations who demonstrated a longer progression-free survival with vitamin C treatment

si- RRM1 , 2 10 5

The lower recruitment of SHP-1 might either be due to changes in its conformation or the serine phosphorylation of Lck, which prevents SHP-1 binding

366 Isotopic labelling studies revealed that the hydrolysis proceeds via the attack of a hydroxide ion on the platinum(IV) center, and not at the carbonyl of the haloacetate

Generation of nitric oxide (NO) was measured by Griess reaction 27