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Loren Pickart first isolated this compound from human plasma in 1973 while researching why aged liver tissue could be stimulated to function like younger tissue when exposed to certain blood components

PMCID: PMC5855430

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These findings highlight the potential of A1AT augmentation therapy to modulate the inflammatory response in A1ATD, reduce neutrophil-mediated damage, and improve clinical outcomes in various manifestations of the disease, including lung inflammation and panniculitis

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