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A personalized, balanced approach to antioxidant therapy is essential, alongside the development of biomarkers and standardized protocols to ensure redox homeostasis and avoid potential harm.

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This review examines studies on iron metabolism, regulation via the hepcidin-ferroportin pathway, myocardial energy, oxidative stress, and clinical trials of iron supplementation or reduction in heart failure, chronic kidney disease, the elderly, women, and athletes

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