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Vitamin B12 absorption occurs primarily in the terminal ileum through intrinsic factor-mediated absorption (for both dietary and supplemental B12) and passive diffusion (particularly relevant for high-dose supplements)

Dumoulin, E

During aging, there is a decrease in mitochondrial biogenesis-related proteins (SIRT1 and PGC-1) and mitophagy-related proteins (PINK1 and PARKIN)

Pearsons correlation coefficients between the measurements were 0.920 for T 1 , 0.906 for T 2 , 0.891 for QSM, 0.991 for T 2 *, 0.989 for B 0 and 0.992 for B 1

the question is whether the supplement you choose can actually get this powerful nutrient to your cells