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This change in the binding affinity of NBD-Sph to the NTD of NCR1 could be caused by an altered hydrogen binding capacity of the sphingosine backbone when the pH changes, as has been shown to take place for natural sphingosine (47)

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3 It is seen when factors that increase remnant lipoprotein production overwhelm the receptor-mediated clearance pathways

Beyond that, case studies raise quite a few red flags for more serious effects

the punishment for a violation of the edict being a fine of only four hundred and fifty dollars, too small to make shipping merchants long hesitate about the risk where such enormous profits were promised