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New drug therapies have begun to focus on combination therapy using medications that target more than one of these central pathways, thereby achieving more favorable weight loss outcomes

doi: 10.1016/j.psyneuen.2014.07.013

These include the glycine co-agonist site on the NMDA complex (strychnine-insensitive), the glycine receptor site (strychnine-sensitive), the GABA-A receptor, the GABA-C receptor, and the GAT proteins

Lyophilized (freeze-dried) peptides often appear as a solid white puck or cake at the bottom of the vial rather than a loose powder