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Neuronal Metabolism and Neuroprotection: Neuroprotective Effect of Fingolimod on Menadione-Induced Mitochondrial Damage Antonio Gil, Elisa Martn-Montaez, Nadia Valverde, Estrella Lara, Federica Boraldi, Silvia Claros, Silvana-Yanina Romero-Zerbo, Oscar Fernndez, Jose Pavia, Maria Garcia-Fernandez PMID: 33383658 DOI: 10.3390/cells10010034 Abstract Imbalance in the oxidative status in neurons, along with mitochondrial damage, are common characteristics in some neurodegenerative diseases

However, the GSH-, TRx- and GRx-systems use NADPH as a source of reducing equivalents, demonstrating an interesting thermodynamical connection between these systems (Figure 1: Regeneration)

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