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It has been demonstrated that all these pathological mechanisms triggered simultaneously by HI associated with IR produce, both directly and indirectly, through the triggering of arterial hypertension, an increase in LV mass, also due to an increase in intramyocardial and epicardial fat, with concentric LV remodeling, increased myocardial fibrosis, and diastolic dysfunction

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Evidence is provided that asymptomatic meningococcal carriage on the nasopharyngeal mucosal surface is facilitated by localized hypermutation in contingency genes, which, together with horizontal gene transfer, affects the expression of a plethora of surface determinants involved in meningococcal adhesion, metabolism, intracellular survival, intra-species and interspecies competition, and escape of immune response (Green et al., 2020)

Gadoteridol was found to be eliminated more rapidly from rat cerebellum, cerebrum, and skin, compared to gadoteric acid and to gadobutrol, in the first 5 weeks after repeated administration of these macrocyclic GBCAs, resulting in lower levels of retained Gd (III) in these tissues [130]