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(2004) suggest that constitutive activity depends on several residues on the inner face of GHSR1a, which seem unlikely to be locations important for the dimerization interface

doi: 10.1093/cvr/cvab127 73 HertzL.RothmanD

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Later, in the 1980s, the development of high-pressure liquid chromatography methods allowed for rapid determination of homocysteine concentrations in 1000s of samples, thus paving the way for epidemiological studies that revealed significant associations between relatively small elevations of homocysteine in blood and cardiovascular, cerebrovascular, and peripheral vascular diseases (7, 46)