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in reply to I understand that spots are common, but severe acne for months and months
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The dose may be increased to achieve a maximum therapeutic effect, at intervals of 3 to 4 days, to a maximum daily dose of 4 mg, given in divided doses
[DOI] [PMC free article] [PubMed] [Google Scholar] 65.Pache de Faria Guimaraes L., Seguro A.C., Shimizu M.H., Lopes Neri L.A., Sumita N.M., de Bragana A.C., Aparecido Volpini R., Cunha Sanches T.R., Macaferri da Fonseca F.A., Moreira Filho C.A., et al
