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Beyond its canonical role in mediating vitamin D actions, VDR functions as a direct sensor for specific gut microbiota-derived secondary BAs, notably lithocholic acid (LCA) and its oxidized derivative 3-oxoLCA (71, 105)

In extrahypothalamic regions, GHSR 1 a is expressed predominantly in the hippocampus , and in dopaminergic midbrain neurons

TABLE 2 A summary of different types of nanoparticles, the loaded cargo, particle size, and advantages of drug encapsulation in melsma management

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Horm Res 2000