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This structural change allows for enhanced interaction with IGF-1 receptors, leading to increased activation of the PI3K/Akt pathway, which plays a central role in protein synthesis and cellular regeneration

The role and relative importance of IGF-1 signaling likely differs between muscle atrophy models, and further studies are required to develop effective strategies to apply IGF-1 to treat muscle atrophy in human patients

Available online at: 21

DOI: 10.1111/jnc.14250 10
