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Statements Author contributions LY: Conceptualization, Writing original draft, Writing review & editing

CVD is the leading cause of death worldwide, the association with gut microbiota has been reported in recent few years, which is mediated by gut microbiota derived metabolites (Wang et al., 2011

Caffeine, the primary active ingredient, acts through adenosine receptor antagonism and increased calcium release, potentially provoking arrhythmias and myocardial stress

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All authors reviewed the manuscript
