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Exerts potent anti-inflammatory effects in the gut and CNS by modulating nitric oxide pathways and reducing pro-inflammatory cytokines, closely resembling the protective actions of the native gastric peptide in response to mucosal injury

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Annu Rev Neurosci 31:175193 Brys M, Fanning L, Hung S, Ellenbogen A, Penner N, Yang M, Welch M, Koenig E, David E, Fox T (2019) Randomized phase I clinical trial of anti-synuclein antibody BIIB054

& Woerpel, K

Furthermore, the connection between the GM and the host not only affects 5-HT production but may also be regulated by feedback from 5-HT levels (251), although this bidirectional regulatory mechanism requires additional exploration