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Therapy of the Rat Hemorrhagic Cystitis Induced by Cyclophosphamide

Interestingly, the inhibitor CPD-3B is virtually non-toxic to normal cells, while targeting not only GLS1 and GDH but also thioredoxin reductase (TrxR) and amidotransferase (GatCAB), resulting in the selective elimination of cancerous cells through a multifaceted mechanism

Inhibition of TLGST with the metal chelating agent EDTA suggested it as a metalloenzyme

Since there is not enough intrinsic factor for vitamin B12 to bind with and it cannot travel to the distal ileum to absorb into the blood, the body cannot absorb vitamin B12 properly

A., Germain, A., Huang, Y