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Description
These metabolic improvements appeared to start before significant weight loss was visible, suggesting that disrupting white fat vasculature has metabolic effects beyond simple fat reduction

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(3) selection bias (only people with good tolerance continue use)
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[DOI] [PubMed] [Google Scholar] Bragg 2010 Bragg F, Cromwell DA, Edozien LC, GurolUrganci I, Mahmood TA, Templeton A, et al
