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PetrovaMIvan den BroekMBalzariniJVanderleydenJLebeerS

It participates in inhibition of vascular wall growth, platelet aggregation, adhesion of monocytes to the vascular endothelial cells (VECs), as well as suppression of VCAM and chemokine monocyte chemoattractant protein 1 (MCP-1) expression and inspiration of platelet cyclic guanosine monophosphate (cGMP) production

In a year-long trial involving 50 HIV-infected patients who had been treated with antiretroviral drugs for an average of six years and had developed metabolic syndrome, metformin treatment significantly slowed the rate of coronary artery calcification compared to lifestyle modification

Strieth-Kalthoff, F., James, M

R., Bobrik, A., Davison, A