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In addition to the kidneys, blood vessels, nerves, and heart, the eyes are greatly affected leading to diabetic retinopathy

In the study, skin biopsy was used to establish the diagnosis of small-fiber neuropathy because of its high specificity, 91%, but it has lower sensitivity, 58% (Saltin et al., 1968

Further, in a recent report from the European PREDIMED study, individuals homozygous for the Cys/Cys genotype had increased total mortality, attributable to cardiovascular disease-related deaths, but not to cancer-related mortality [210]

10.1002/14651858.CD005573.pub3

Therefore, exploring natural compounds for the prevention and treatment of ASCVD is of critical importance, as it holds the potential to offer substantial benefits in managing this condition