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Key publications include the original characterization study (PubMed: 930790), stress response research (PubMed: 7540925), and neuroendocrine effects (PubMed: 2547858)

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The recommendation of 8 to 10 glasses of water daily becomes particularly relevant during active healing protocols

Monitoring strategies should include assessment of gastrointestinal symptoms, changes in bowel habits, and relevant biomarkers depending on the clinical indication

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