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Description
Individuals with moderate glutathione synthetase deficiency may experience symptoms beginning shortly after birth including hemolytic anemia, 5-oxoprolinuria, and elevated acidity in the blood and tissues (metabolic acidosis)
In another work, Gondim et al

Carbon dioxide/bicarbonate is required for sensitive inactivation of mammalian glyceraldehyde-3-phosphate dehydrogenase by hydrogen peroxide

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The formation of HSPs in ME/CFS individuals is reduced (302), and the responses of plasma HSP27 and HSP70 are delayed or lowered, while resting levels of plasma HSP70 are also decreased (303)
