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A sex-stratified analysis by van Kleef et al

However, Figure 5 is probably an oversimplification, because both CL and Vd can change in acute and chronic clinical situations, such as sepsis, kidney disease, and liver disease
O.SonawaneB.2009The influence of genetic polymorphisms on population variability in six xenobiotic-metabolizing enzymes.125-6, (2009),307333,1093-7404 37

In participants with mild Alzheimers disease after 1 year of treatment there was a reported 18% less cognitive decline and 50% reduced brain shrinkage compared to placebo