ed schimt glutathione RIPK1 ablation in T cells results in spontaneous enteropathy and TNF-driven villus atrophy | EMBO Reports Role of Reactive Oxygen Species

de Brito OM, Scorrano L

Lajin, B., Alhaj Sakur, A., Michati, R

This review highlights the limitations of conventional approaches and explores alternative strategies, including LT4+LT3 combination therapy, total thyroidectomy, and adjunctive treatments such as supplements, herbal medicine, and acupuncture

Studies are needed to establish the relationship between extracellular and intracellular glutathione in its oxidised and reduced form because intracellular may ultimately be a better biomarker to study cellular effects proposed in theoretical models

Risk factors include the speed and magnitude of weight loss, pre-existing nutritional deficiencies, age, sex (women are more commonly affected), and individual genetic susceptibility