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Practical Interpretation The mechanistic plausibility (NNMT NAD SIRT1/PGC-1 BMR & fat oxidation) is strong and consistent across preclinical models
But once you start researching, you quickly see that the two treatments work differently, deliver different results, and are not equally effective for everyone
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Effects of intermittent and chronic calorie restriction on mammalian target of rapamycin (mTOR) and IGF-I signaling pathways in mammary fat pad tissues and mammary tumors
Toxicology 254 , 130135 (2008)
