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The N-terminal half of the AASS protein harbors the lysine:2-oxoglutarate reductase activity and the C-terminal half harbors the saccharopine dehydrogenase activity

Marcocci C, Kahaly GJ, Krassas GE, Bartalena L, Prummel M, Stahl M et al (2011) Selenium and the course of mild Graves orbitopathy

The sample size of 30 patients in each group was required to achieve a power of 90% with alpha = 0.05 to detect a medium to large effect size of 0.86 in post-operative troponin I level

However, many cases with phenotypes different from those described by Werdnig have since been reported