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(123) found that in BCAECs, TPs activated ERK1/2 and inhibited p38MAPK signaling in a dose-dependent manner, downregulating Cav-1 expression and thereby protecting endothelial cells

Second-generation compounds like GHRP-2 and hexarelin improved potency and partially reduced some off-target effects but still elevated cortisol and prolactin at effective GH-releasing concentrations

Collino M, Pini A, Mugelli N, Mastroianni R, Bani D, Fantozzi R, et al
