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Quantification was performed by an investigator blinded to sample identity

Important proteins here are HIF1, nuclear factor kappa B (NFkB), PPARs, NRF1, and NRF2

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Additionally, a meta-analysis of multiple randomized, controlled trials confirmed that tesamorelin treatment significantly lowered visceral fat area and trunk fat, reduced hepatic fat, and was associated with a statistically significant increase in lean body mass, supporting its clinical effect on fat distribution and muscle preservation

Schulthei et al., 2022)