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During the ischemic phase, iron metabolism imbalance (upregulation of Hmox1 and TF, downregulation of iron transport protein FPN) leads to iron accumulation, while the reperfusion phase accelerates oxidative stress through ROS explosion, synergistically driving ferroptosis mediated by ACSL4-induced lipid peroxidation (Guo et al., 2023)

Journal of Pharmaceutical Sciences, 109(12), 36533659

Injection site reactions are localized, which means the side effect is limited to the area around the injection, not your whole body

Hegab, Z

Liver fibrosis is a key determinant of disease progression, and higher fibrosis stages are associated with an increased risk of liver related complications, including cirrhosis, HCC, and liver failure [45]