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Pain 155, 16051612 (2014)

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Sikiric P, Separovic J, Buljat G, Anic T, Stancic-Rokotov D, Mikus D, Marovic A, Prkacin I, Duplancic B, Zoricic I, Aralica G, Lovric-Bencic M, Ziger T, Perovic D, Rotkvic I, Mise S, Hanzevacki M, Hahn V, Seiwerth S, Turkovic B, Grabarevic Z, Petek M, Rucman R

Compared to db/m mice, potential interactions between PT AQP4+ and the other PT subtypes (PTS1/2 and PTS3) including C3-CD81, FGG-ITGAV, and GC-LRP2 axis were only found in db/db mice (Fig

Research suggests it acts through modulation of several interconnected signaling pathways simultaneously a broad mechanism of action that helps explain its observed multisystemic effects in laboratory models, and that also makes it challenging to evaluate through conventional single-target drug development frameworks