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showed in their genome-wide DNA methylation study of unaffected frontal brain white matter of cALD and AMN patients that oligodendrocyte-differentiation related genes such as MBP, CNP, MOG, and PMP1 were hypermethylated and the genes of immune functions such as IFITM1 and CD59 were hypomethylated [84]

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Maurer GD, Brucker DP, Bhr O, Harter PN, Hattingen E, Walenta S et al

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There are also indications of an upregulation of ABCG2 in correlation with an inflammatory marker in human brain tissue 49

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10.1007/s00253-019-09698-y 198 MiW.MengM.XuF.SunL

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