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Ferroptosis agonists directly or indirectly affect glutathione peroxidase (GPXs) through various pathways, leading to a reduction in antioxidant capacity, accumulation of ROS, and ultimately oxidative cell death (115, 116)

Several studies reported that chronic microglial activation resulted in elevated levels of IL-1, IL-6, and TNF- in the striatum and substantia nigra pars compacta of patients with PD [61, 62]

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In summary, oxidative stress drives the occurrence and progression of CVDs, and the GSH system is positively involved in antioxidant activity, which is beneficial to their treatment and prognosis

Cisplatin resistance and opportunities for precision medicine