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If you feel tired all the time, even after a full nights rest, it may be due to low B12 levels

First, we must determine whether the interaction exists as a genuine metabolic and physiologic phenomenon, and define the dose at which excess folate produces the effect

Vitamin B12 deficiency happens when you have lack certain vitamins in your body

Medications including metformin, proton pump inhibitors, and H2-receptor antagonists may reduce absorption of B12, potentially prolonging the time to clinical improvement

Symptoms of pernicious anemia can vary, but common symptoms include: Depression and irritability Difficulty maintaining balance Fatigue and weakness Heart palpitations Loss of appetite Numbness or tingling in the hands and feet Pale skin Shortness of breath Weight loss Can I have pernicious anemia without having symptoms