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Any known tolerability profile in studies

At baseline and at weeks 8 and 12, a clinician should assess fasting insulin and HOMA-IR (the homeostasis model assessment of insulin resistance, a calculated index derived from fasting glucose and insulin), HbA1c, high-sensitivity C-reactive protein as an inflammatory marker, and body composition by DEXA scan or bioelectrical impedance

Ziziphus spina-christi fruit extract suppresses oxidative stress and p38 MAPK expression in ulcerative colitis in rats via induction of Nrf2 and HO-1 expression

Still, it is important to consider possible sensitization, especially in patients with pre-existing skin conditions

And because it is derived from a naturally occurring protein, its mechanism of action works with existing biological pathways rather than introducing foreign signaling