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Emerging data suggests multi-agonist compounds may result in a different lean mass profile compared to GLP-1only peptides, although research is ongoing

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Sitagliptin (20 mg/kg/day, orally) was given for 5 days before cyclophosphamide administration at a single dose of 200 mg/kg, i.p on day 5

Transgenic overexpression of insulin-like growth factor I prevents streptozotocin-induced cardiac contractile dysfunction and ??-adrenergic response in ventricular myocytes