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Reduced kidney function and folate status are major confounders, since both can raise MMA and/or homocysteine independently of B12

Side Effects & Precautions: Common Side Effects: Mild pain or swelling at the injection site Rare allergic reactions Headache or nausea in some cases Precautions: Pregnant or breastfeeding women should consult a doctor Patients with kidney/liver conditions should follow customized dosage FAQs Q

[3, 5, 7] Taking vitamin B12 while pregnant is often deemed a good idea, as it may lower the risk of acute lymphoblastic leukaemia in children, which is why vitamin B12 is usually found in supplements for pregnant women alongside folate (vitamin B9)

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People with normal vitamin B-12 levels have sufficient vitamin B-12 stores to make the effects of nitrous oxide insignificant, unless exposure is repeated and prolonged (such as recreational use)