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Symptoms of a deficiency are therefore most likely to occur as different body parts become deprived of nutrients and oxygen

BMC Neurol 17:220 Sheffer R, Douiev L, Edvardson S, Shaag A, Tamimi K, Soiferman D, Meiner V, Saada A (2016) Postnatal microcephaly and pain insensitivity due to a de novo heterozygous DNM1L mutation causing impaired mitochondrial fission and function

The TH gene is located on chromosome 11p15.5 and is composed of 14 exons that generate three alternatively spliced mRNAs that encode tyrosine hydroxylase isoform a (528 amino acids), isoform b (497 amino acids), and isoform c (524 amino acids)

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