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Supplements are not appropriate for everyone

First, SELECT was not a primary prevention trial, and the data should not be extrapolated to all individuals with overweight and obesity to prevent major adverse CV events

Patients with a personal or family history of medullary thyroid carcinoma should not take these drugs

While semaglutide offers significant benefits for weight loss and diabetes management, its impact on the gastrointestinal system, including delayed gastric emptying, can interfere with nutrient absorption

Oral Supplements Oral B12 supplements are convenient and effective for many patients, especially those with low B12 intake due to dietary choices (e.g., vegetarians or vegans), older adults, or those with no significant absorption issues